The crash took place around 5:53 p.m. Thursday in the area of the Valvoline Instant Oil Change, 1788 South Road, in Wappingers Falls, said Town of Poughkeepsie Police Capt. Kevin Faber.
According to Faber, a 2014 Nissan Maxima, driven by a 23-year-old from Hialeah, Florida, was traveling southbound on South Road when the driver lost control of the vehicle.
The vehicle crossed the median and hit a northbound 2007 Honda Accord, driven by a 63-year-old Beacon man, Faber said.
The Maxima driver suffered non-life threatening injuries and was transported to an area hospital.
The driver of the Honda and his passenger, a 74-year-old Beacon woman, sustained serious injuries and were transported to the hospital, he added.
The roadway was partially shut down to traffic for more than three hours during the crash investigation.
The Town of Poughkeepsie Police Department was assisted at the scene by the New Hamburg Fire Department, Mobile Life Ambulance, and the New York State Police.
The investigation is ongoing. Anyone who may have witnessed the crash is asked to contact the Traffic Enforcement Unit at 845-485-36890.
Click here to follow Daily Voice Middletown-Wallkill and receive free news updates.